CPT procedure code

81405

Medicare payment

$301.35

2026 Clinical Laboratory Fee Schedule

Source: CMS Clinical Laboratory Fee Schedule (2026). CMS fee schedules ↗ · PFS status indicator X

National amount before geographic adjustment. Your MAC's locality rate will differ.

Code definition

Code

81405

Code system

CPT (Current Procedural Terminology)

This CPT code is not in our curated reference. CPT codes are maintained by the American Medical Association (AMA). Full descriptions require an AMA license.

Category

Short description sourced from CMS publicly available fee schedule data. Full CPT descriptions are copyright AMA. Not a substitute for the official CPT codebook.

Policy activity for CPT 81405

CLV Intelligence is tracking 11 policy changes that cite CPT 81405 most recently on 2026-06-05, drawn from 8 LCD/NCD coverage updates and 3 proposed LCDs. The changes span Clinical Laboratory, Multi-specialty and Oncology. 6 are flagged critical or high priority.

LCD/NCD coverage updates
8
proposed LCDs
3

Counts reflect the source documents CLV has matched to CPT 81405 to date; each links to the government publication that is authoritative. Monitored daily from CMS, the Federal Register, and Medicare Administrative Contractor publications.

Policy changes matched to 81405

Matched to this code by CLV analysis of each policy. The linked source document is authoritative.

LCD L36256: MolDX: Molecular Diagnostic Tests (MDT) — Noridian

Clinical Laboratory · LCD-L36256

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

View alert

LCD L36021: MolDX: Molecular Diagnostic Tests (MDT) — CGS

Clinical Laboratory · LCD-L36021

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

View alert

LCD L35160: MolDX: Molecular Diagnostic Tests (MDT) — Noridian

Clinical Laboratory · LCD-L35160

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

View alert

LCD L39040: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer — WPS

Oncology · LCD-L39040

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

View alert

LCD L39017: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer — CGS

Oncology · LCD-L39017

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

View alert

Proposed LCD DL35000: Molecular Pathology Procedures — NGS

Multi-specialty · LCD-DL35000

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

View alert

LCD L38972: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer — Noridian

Oncology · LCD-L38972

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

View alert

LCD L38974: MolDX: Lab-Developed Tests for Inherited Cancer Syndromes in Patients with Cancer — Noridian

Oncology · LCD-L38974

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

View alert

Proposed LCD DL39927: MolDX: Non-Next Generation Sequencing Tests for the Diagnosis of BCR-ABL Negative Myeloproliferative Neoplasms — Noridian

Oncology · LCD-DL39927

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

View alert

Proposed LCD DL40142: MolDX: Biomarker Testing for Risk Stratification in DCIS — Palmetto GBA

Oncology · LCD-DL40142

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

View alert

Audit documentation

Building an audit file that includes CPT 81405?

The Tripwire Audit Pack exports 12 months of single-specialty policy-change history — every alert with a link to its government source document, as a formatted PDF for compliance distribution plus a machine-readable CSV. Delivered automatically after payment. No account, no call.

See audit packs — $349One-time purchase · not a subscription

Get alerts when policy changes affect 81405

Free weekly digest — no subscription required.

Look up another code

Search ICD-10, HCPCS, or CPT codes with related reimbursement alerts.

Code lookup