CPT procedure code

81542

Medicare payment

$3,873.00

2026 Clinical Laboratory Fee Schedule

Source: CMS Clinical Laboratory Fee Schedule (2026). CMS fee schedules ↗ · PFS status indicator X

National amount before geographic adjustment. Your MAC's locality rate will differ.

Code definition

Code

81542

Code system

CPT (Current Procedural Terminology)

This CPT code is not in our curated reference. CPT codes are maintained by the American Medical Association (AMA). Full descriptions require an AMA license.

Category

Short description sourced from CMS publicly available fee schedule data. Full CPT descriptions are copyright AMA. Not a substitute for the official CPT codebook.

Policy activity for CPT 81542

CLV Intelligence is tracking 11 policy changes that cite CPT 81542 most recently on 2026-06-05, drawn from 10 LCD/NCD coverage updates and 1 proposed LCD. The changes span Clinical Laboratory, Multi-specialty, Oncology and Urology. 4 are flagged critical or high priority.

LCD/NCD coverage updates
10
proposed LCD
1

Counts reflect the source documents CLV has matched to CPT 81542 to date; each links to the government publication that is authoritative. Monitored daily from CMS, the Federal Register, and Medicare Administrative Contractor publications.

Policy changes matched to 81542

Matched to this code by CLV analysis of each policy. The linked source document is authoritative.

LCD L36256: MolDX: Molecular Diagnostic Tests (MDT) — Noridian

Clinical Laboratory · LCD-L36256

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

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LCD L36021: MolDX: Molecular Diagnostic Tests (MDT) — CGS

Clinical Laboratory · LCD-L36021

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

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LCD L35160: MolDX: Molecular Diagnostic Tests (MDT) — Noridian

Clinical Laboratory · LCD-L35160

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

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LCD L38292: MolDX: Prostate Cancer Genomic Classifier Assay for Men with Localized Disease — Palmetto GBA

Oncology · LCD-L38292

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

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LCD L38341: MolDX: Prostate Cancer Genomic Classifier Assay for Men with Localized Disease — Noridian

Oncology · LCD-L38341

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

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LCD L38303: MolDX: Prostate Cancer Genomic Classifier Assay for Men with Localized Disease — CGS

Oncology · LCD-L38303

Government source· CMS / MACverify ↗
Routine

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LCD L38339: MolDX: Prostate Cancer Genomic Classifier Assay for Men with Localized Disease — Noridian

Oncology · LCD-L38339

Government source· CMS / MACverify ↗
Routine

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LCD L39686: MolDX: Gene Expression Profile Tests for Decision-Making in Castration Resistant and Metastatic Prostate Cancers — Noridian

Oncology · LCD-L39686

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

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Proposed LCD DL35000: Molecular Pathology Procedures — NGS

Multi-specialty · LCD-DL35000

Government source· CMS / MACverify ↗
High

Full analysis available with a CLV subscription.

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LCD L39688: MolDX: Gene Expression Profile Tests for Decision-Making in Castration Resistant and Metastatic Prostate Cancers — Noridian

Urology · LCD-L39688

Government source· CMS / MACverify ↗
Routine

Full analysis available with a CLV subscription.

View alert

Audit documentation

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