LCD L38680: MolDx: Molecular Testing for Solid Organ Allograft Rejection — WPS
Policy LCD-L38680 • Clinical Laboratory
CriticalThis final LCD from WPS (J5/J8) governs molecular testing for solid organ allograft rejection and is now retired as of its last update, meaning coverage policies under L38680 are no longer active for
LCD L40274: MolDX: Genetic Testing for Hereditary Thrombophilia — WPS
Policy LCD-L40274 • Clinical Laboratory
CriticalThis final LCD from WPS (J5/J8) establishes coverage criteria for genetic testing related to hereditary thrombophilia, effective October 12, 2026, across six Midwestern states. Providers should review
LCD L40259: MolDX: Genetic Testing for Hereditary Thrombophilia — CGS
Policy LCD-L40259 • Clinical Laboratory
CriticalThis final LCD from CGS (J15) establishes coverage criteria for genetic testing related to hereditary thrombophilia under the MolDX program, effective October 12, 2026, for Kentucky and Ohio providers
LCD L40222: MolDX: Non-Next Generation Sequencing Targeted Molecular Panel Tests for Targeted Therapy in Cancer — Noridian
Policy LCD-L40222 • Clinical Laboratory
CriticalThis final LCD from Noridian (JE, JF) establishes coverage criteria for non-next generation sequencing (non-NGS) targeted molecular panel tests used to guide targeted therapy decisions in cancer patie
LCD L40242: MolDX: Genetic Testing for Hereditary Thrombophilia — Noridian
Policy LCD-L40242 • Clinical Laboratory
CriticalThis final LCD from Noridian (Jurisdictions E and F) establishes coverage criteria for MolDX genetic testing for hereditary thrombophilia, effective October 12, 2026, across 15 Western and Mountain st
LCD L40238: MolDX: Genetic Testing for Hereditary Thrombophilia — Palmetto GBA
Policy LCD-L40238 • Clinical Laboratory
CriticalThis final LCD from Palmetto GBA establishes coverage criteria for genetic testing related to hereditary thrombophilia, effective October 12, 2026, across seven southeastern states under Part A and Pa
CMS Transmittal R13921CP: NCD 210.3 Screening for Colorectal Cancer-Non-Invasive Biomarker Tests
Policy CMS-T-R13921CP • Clinical Laboratory
CriticalCMS is updating NCD 210.3 for colorectal cancer screening via non-invasive biomarker tests, with claims processing changes effective January 4, 2027. Billing teams must review and update their coding
CMS Transmittal R13921NCD: NCD 210.3 Screening for Colorectal Cancer-Non-Invasive Biomarker Tests
Policy CMS-T-R13921NCD • Clinical Laboratory
CriticalCMS is updating NCD 210.3 to revise coverage policy for non-invasive biomarker-based colorectal cancer screening tests under Medicare. Billing teams should prepare for updated coverage criteria, eligi
CMS Transmittal R13884CP: October 2026 Quarterly Update to the Clinical Laboratory Fee Schedule (CLFS) and Clinical…
Policy CMS-T-R13884CP • Clinical Laboratory
CriticalThis transmittal implements the October 2026 quarterly update to the Clinical Laboratory Fee Schedule (CLFS), effective October 5, 2026. Billing teams should anticipate updated payment rates and poten
LCD L33573: B-type Natriuretic Peptide (BNP) Testing — Wellpoint Federal
Policy LCD-L33573 • Clinical Laboratory
HighThis active, final LCD from Wellpoint Federal governs coverage criteria for B-type Natriuretic Peptide (BNP) testing under both Part A and Part B, effective April 1, 2026. It establishes the indicatio
LCD L35074: Heavy Metal Testing — Wellpoint Federal
Policy LCD-L35074 • Clinical Laboratory
HighThis final LCD from Wellpoint Federal establishes coverage criteria for heavy metal testing under Medicare Part A and B, effective April 1, 2026. It defines medically necessary indications for orderin
LCD L39189: Mass Spectrometry (MS) Testing in Monoclonal Gammopathy (MG) — Wellpoint Federal
Policy LCD-L39189 • Clinical Laboratory
HighThis active final LCD from Wellpoint Federal establishes coverage criteria for mass spectrometry testing in monoclonal gammopathy, effective April 1, 2026. It governs when MS-based diagnostic tests (s
LCD L39726: KidneyIntelX and KidneyIntelX.dkd Testing — Wellpoint Federal
Policy LCD-L39726 • Clinical Laboratory
HighThis active Final LCD (L39726) from Wellpoint Federal establishes coverage criteria for KidneyIntelX and KidneyIntelX.dkd testing, effective April 1, 2026. It defines the conditions under which these
LCD L39995: Pharmacogenomic Testing — Wellpoint Federal
Policy LCD-L39995 • Clinical Laboratory
HighThis final LCD from Wellpoint Federal establishes coverage criteria for pharmacogenomic testing under Medicare Part A and Part B, effective April 1, 2026. It defines when genetic testing to guide drug
LCD L39611: Urine Drug Testing — Wellpoint Federal
Policy LCD-L39611 • Clinical Laboratory
HighThis final LCD from Wellpoint Federal governs coverage criteria for urine drug testing under both Part A and Part B, effective April 1, 2026. It establishes the clinical indications, documentation req
LCD L37535: Vitamin D Assay Testing — Wellpoint Federal
Policy LCD-L37535 • Clinical Laboratory
HighThis final LCD from Wellpoint Federal governs coverage of Vitamin D assay testing under Medicare Part A and Part B, effective April 1, 2026. It establishes specific clinical indications, documentation
LCD L33591: RAST Type Tests — Wellpoint Federal
Policy LCD-L33591 • Clinical Laboratory
HighThis active final LCD from Wellpoint Federal governs coverage criteria for RAST (radioallergosorbent) type allergy tests under Medicare Part A and B, effective April 1, 2026. It establishes the indica
LCD L40058: MolDX: Molecular Testing for Solid Organ Allograft Rejection — Palmetto GBA
Policy LCD-L40058 • Clinical Laboratory
HighThis final LCD from Palmetto GBA establishes coverage criteria for molecular testing used to detect solid organ allograft rejection, taking effect August 30, 2026. It applies to both Part A and Part B
LCD L40060: MolDX: Molecular Testing for Solid Organ Allograft Rejection — Noridian
Policy LCD-L40060 • Clinical Laboratory
HighThis final LCD from Noridian (JE/JF) establishes coverage criteria for molecular testing used to detect solid organ allograft rejection, taking effect August 30, 2026. It will govern Medicare reimburs
LCD L40062: MolDX: Molecular Testing for Solid Organ Allograft Rejection — Noridian
Policy LCD-L40062 • Clinical Laboratory
HighThis final LCD from Noridian establishes coverage criteria for molecular testing used to detect solid organ allograft rejection, effective August 30, 2026. It will define which patients, organ types,
LCD L40249: MolDX: Molecular Testing for Solid Organ Allograft Rejection — WPS
Policy LCD-L40249 • Clinical Laboratory
HighThis final LCD from WPS (J5/J8) establishes coverage criteria for molecular testing used to detect solid organ allograft rejection, effective August 30, 2026. It applies to Medicare Part A and Part B
LCD L40140: MolDX: Molecular Testing for Solid Organ Allograft Rejection — CGS
Policy LCD-L40140 • Clinical Laboratory
HighThis final LCD from CGS (J15) governs molecular testing for solid organ allograft rejection in Kentucky and Ohio, effective August 30, 2026. It establishes coverage criteria and documentation requirem
CMS Transmittal R13849CP: Changes to the Laboratory National Coverage Determination (NCD) Edit Software for October 2026…
Policy CMS-T-R13849CP • Clinical Laboratory
CriticalCMS is updating the Laboratory NCD Edit Software effective October 5, 2026, to reflect changes in National Coverage Determinations for lab services. Billing teams must review updated NCD edits in thei
CMS Transmittal R13855CP: July 2026 Quarterly Update to the Clinical Laboratory Fee Schedule (CLFS) and Clinical…
Policy CMS-T-R13855CP • Clinical Laboratory
HighThis transmittal implements the July 2026 quarterly update to the Clinical Laboratory Fee Schedule (CLFS), effective July 6, 2026. Billing teams must update their lab fee schedule tables to reflect th
LCD L40272 (Notice Ends 08/09/2026): MolDX: Biomarker Testing in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis — WPS
Policy LCD-L40272 • Clinical Laboratory
HighLCD L40272 establishes coverage criteria for MolDX biomarker testing in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH), ef
LCD L40199 (Notice Ends 08/09/2026): MolDX: Biomarker Testing in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis — CGS Administrators
Policy LCD-L40199 • Clinical Laboratory
HighLCD L40199 covers MolDX biomarker testing for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH), effective 08/10/2026 under C
LCD L40197 (Notice Ends 08/09/2026): MolDX: Biomarker Testing in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis — Noridian
Policy LCD-L40197 • Clinical Laboratory
HighThis future LCD (effective 08/10/2026) from Noridian covers MolDX biomarker testing for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepa
LCD L40187 (Notice Ends 08/09/2026): MolDX: Biomarker Testing in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis — Palmetto GBA
Policy LCD-L40187 • Clinical Laboratory
HighLCD L40187 governs MolDX biomarker testing for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Metabolic Dysfunction-Associated Steatohepatitis (MASH), effective August 10, 2026.
Federal Register Notice: Medicare Program: Public Meeting Regarding New and Reconsidered Clinical Diagnostic Laboratory Test Codes for the Clinical Laboratory Fee Schedule for Calendar Year 2027
Policy FR-2026-08511 • Clinical Laboratory
RoutineThe upcoming public meeting for the Clinical Laboratory Fee Schedule will focus on new and reconsidered test codes, which could significantly influence payment amounts for laboratories. Stakeholders a
Federal Register Notice: Medicare Program: Public Meeting Regarding New and Reconsidered Clinical Diagnostic Laboratory Test Codes for the Clinical Laboratory Fee Schedule for Calendar Year 2026-June 27, 2025
Policy FR-2025-06756 • Clinical Laboratory
RoutineThe upcoming public meeting will impact the reimbursement strategies for new and revised clinical diagnostic laboratory test codes under the Clinical Laboratory Fee Schedule (CLFS) for 2026. Stakehold
Federal Register Notice: Public Meeting on June 25, 2024 Regarding New and Reconsidered Clinical Diagnostic Laboratory Test Codes for the Clinical Laboratory Fee Schedule for Calendar Year 2025
Policy FR-2024-08005 • Clinical Laboratory
RoutineThe upcoming public meeting on June 25, 2024, will address new and reconsidered clinical diagnostic laboratory test codes impacting the Clinical Laboratory Fee Schedule for 2025. Stakeholders will hav
Federal Register Notice: Medicare Program; Public Meeting on June 22, 2023 Regarding New and Reconsidered Clinical Diagnostic Laboratory Test Codes for the Clinical Laboratory Fee Schedule for Calendar Year 2024
Policy FR-2023-07909 • Clinical Laboratory
RoutineThe public meeting focuses on establishing payment amounts for new and revised laboratory test codes under the Clinical Laboratory Fee Schedule, potentially impacting reimbursement rates for diagnosti
Proposed LCD DL36351: Lab: Special Histochemical Stains and Immunohistochemical Stains — Noridian
Policy LCD-DL36351 • Clinical Laboratory
RoutineThe proposed local coverage determination (LCD) for histochemical and immunohistochemical stains could impact billing by clarifying guidelines and coverage for these laboratory tests. This may lead to
Proposed LCD DL36353: Lab: Special Histochemical Stains and Immunohistochemical Stains — Noridian
Policy LCD-DL36353 • Clinical Laboratory
RoutineThe proposed Local Coverage Decision regarding special histochemical and immunohistochemical stains may impact billing practices for laboratories. Providers should ensure that they have appropriate do
Proposed LCD DL40058: MolDX: Molecular Testing for Solid Organ Allograft Rejection — Palmetto GBA
Policy LCD-DL40058 • Clinical Laboratory
RoutineThe proposed LCD by Palmetto GBA for molecular testing related to solid organ allograft rejection could impact billing significantly by establishing specific criteria for coverage. This may lead to in
Proposed LCD DL40140: MolDX: Molecular Testing for Solid Organ Allograft Rejection — CGS
Policy LCD-DL40140 • Clinical Laboratory
RoutineThe proposed Local Coverage Determination (LCD) for molecular testing related to solid organ allograft rejection could significantly influence billing practices for relevant tests. With proper coding,
Federal Register Final Rule: Clinical Laboratory Improvement Amendments of 1988 (CLIA) Fees; Histocompatibility, Personnel, and Alternative Sanctions for Certificate of Waiver Laboratories
Policy FR-2023-28170 • Clinical Laboratory
RoutineThe updated CLIA fees will impact reimbursement for clinical laboratory services, potentially increasing costs for laboratories while ensuring sustainable funding for the program. Enhanced fees for fo
LCD L39935: MolDX: Molecular Testing for Identification and Management of Hereditary Transthyretin Amyloidosis — Palmetto GBA
Policy LCD-L39935 • Clinical Laboratory
HighThe new MolDX coverage for hereditary transthyretin amyloidosis testing will provide reimbursement pathways for diagnostic molecular tests, benefiting patients and providers through enhanced testing a
LCD L34011: Ionized Calcium — First Coast
Policy LCD-L34011 • Clinical Laboratory
HighThe effective date of the LCD for Ionized Calcium indicates changes in the coverage and billing practices for this test. This may lead to adjustments in claims processing and reimbursement rates, requ
LCD L33996: Vitamin D Assay Testing — CGS
Policy LCD-L33996 • Clinical Laboratory
HighThe implementation of the new LCD on Vitamin D Assay Testing will impact billing practices significantly. Providers will need to familiarize themselves with the new guidelines to ensure appropriate re
LCD L36692: Vitamin D Assay Testing — Noridian
Policy LCD-L36692 • Clinical Laboratory
HighThe introduction of the new LCD for Vitamin D Assay Testing by Noridian may affect billing practices, ensuring that healthcare providers follow updated guidelines for testing reimbursement. As a resul
LCD L34051: Vitamin D Assay Testing — Noridian
Policy LCD-L34051 • Clinical Laboratory
HighThe recent LCD regarding Vitamin D assay testing by Noridian may impact billing practices significantly, especially in terms of coverage and reimbursement rates. Providers must ensure compliance with
LCD L36021: MolDX: Molecular Diagnostic Tests (MDT) — CGS
Policy LCD-L36021 • Clinical Laboratory
HighThe introduction of the MolDX: Molecular Diagnostic Tests policy will significantly impact billing practices for molecular diagnostics, potentially leading to changes in reimbursement rates. It is cru
LCD L34658: Vitamin D Assay Testing — WPS
Policy LCD-L34658 • Clinical Laboratory
HighThe LCD on Vitamin D Assay Testing by WPS may impact billing by clarifying coverage criteria which may lead to more denials for tests not meeting the outlined requirements. This could require provider
LCD L37616: Lab: Cystatin C Measurement — Noridian
Policy LCD-L37616 • Clinical Laboratory
HighThe new LCD for Cystatin C Measurement by Noridian, effective September 11, 2025, may impact billing practices for clinical laboratories. Providers will need to ensure compliance with the guidelines o
LCD L36351: Lab: Special Histochemical Stains and Immunohistochemical Stains — Noridian
Policy LCD-L36351 • Clinical Laboratory
HighThe introduction of new guidelines for Special Histochemical and Immunohistochemical Stains by Noridian may impact billing practices significantly. Providers should ensure they are familiar with the n
LCD L36353: Lab: Special Histochemical Stains and Immunohistochemical Stains — Noridian
Policy LCD-L36353 • Clinical Laboratory
HighThe new LCD on Special Histochemical and Immunohistochemical Stains is likely to impact lab billing practices significantly by specifying the criteria for coverage. Providers should ensure that their
LCD L37618: Lab: Cystatin C Measurement — Noridian
Policy LCD-L37618 • Clinical Laboratory
HighThe upcoming Local Coverage Determination for Cystatin C Measurement may impact billing practices significantly as of its effective date in February 2025. Providers will need to ensure they understand
LCD L38294: MolDX: Pharmacogenomics Testing — Palmetto GBA
Policy LCD-L38294 • Clinical Laboratory
HighThe introduction of the MolDX Pharmacogenomics Testing LCD by Palmetto GBA may significantly impact the billing for genetic testing services within the specified effective date. Providers must ensure
LCD L38435: MolDX: Pharmacogenomics Testing — WPS
Policy LCD-L38435 • Clinical Laboratory
HighThe new LCD for Pharmacogenomics Testing by WPS may lead to supports compliance with updated rates practices for these tests. Providers will need to ensure that they meet the updated criteria to avoid claim de