LCD L39948: MolDX: Molecular Testing for Identification and Management of Hereditary Transthyretin Amyloidosis — Noridian
Genetic Testing · Effective 2026-02-05
Specialty intelligence
Genetic testing Reimbursement Alerts
1 active CMS and MAC reimbursement alert affect Genetic testing billing teams (High-priority changes active) — most recent: LCD L39948: MolDX: Molecular Testing for Identification and Management of Hereditary Transthyretin Amyloidosis — Noridian, effective 2026-02-05. Monitored daily across CMS, all 16 MAC jurisdictions, and the Federal Register.
Daily CMS policy updates, MAC LCD revisions, and coding guidance for Genetic testingbilling teams. All alerts sourced directly from CMS — including the Medicare Coverage Database that carries every MAC’s LCDs — and the Federal Register.
Total alerts
1
Average signal
63/100
Sources monitored
9
Latest Genetic testing alerts
1What is Genetic testing reimbursement leakage costing you?
Calculate your ROI with Genetic testing-specific CMS benchmarks pre-populated.
MAC contractor coverage
Genetic testing billing is subject to both national CMS policy and regional MAC contractor Local Coverage Determinations (LCDs). Coverage from all seven A/B contractors — Noridian, CGS, First Coast, NGS, Novitas, Palmetto GBA, and WPS — reaches us through the CMS Medicare Coverage Database, where they publish their LCDs and Billing & Coding Articles; we track it there for updates affecting Genetic testing codes. Coverage criteria vary by contractor jurisdiction.
NoridianCGS AdministratorsFirst CoastNational Government ServicesNovitas SolutionsPalmetto GBAWPS
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Weekly digest of CMS and MAC policy changes for Genetic testing billing teams.
Frequently asked questions
What MAC contractors issue LCDs for Genetic testing billing?
Genetic testing billing is subject to regional Local Coverage Determinations (LCDs) from the 7 A/B Medicare Administrative Contractors: Noridian, CGS Administrators, First Coast Service Options, National Government Services, Novitas Solutions, Palmetto GBA, and WPS Government Health Administrators. Between them they administer the 12 A/B MAC jurisdictions; a further 4 DME MAC jurisdictions are administered by Noridian and CGS. Coverage criteria and medical necessity requirements vary by jurisdiction. CLV Intelligence monitors all 16 MAC jurisdictions daily for LCD updates affecting Genetic testing codes.
How often does CMS update Genetic testing reimbursement policy?
CMS updates the Physician Fee Schedule annually, effective January 1, with proposed rules published in the summer and final rules in November. MAC contractors issue LCD updates on a rolling basis throughout the year with no fixed schedule. The Federal Register publishes proposed and final rules affecting Genetic testing reimbursement on a continuous basis. CLV Intelligence monitors all three sources daily and surfaces updates by signal strength.
What is a Local Coverage Determination (LCD) and how does it affect Genetic testing billing?
A Local Coverage Determination (LCD) is a decision by a Medicare Administrative Contractor specifying under what clinical circumstances a particular service is covered within its geographic jurisdiction. For Genetic testing billing teams, LCDs define medical necessity criteria, covered diagnoses, and documentation requirements for specific procedures. Failure to comply with LCD requirements is among the most common causes of Medicare claim denial in Genetic testing practices.
Codes we track for Genetic testing
The CPT/HCPCS and ICD-10 codes most often affected by Genetic testing policy changes we monitor. Each links to its reimbursement-alert history.
Reimbursement guides & resources
Plain-language guides to the policy cycles that drive Genetic testing reimbursement — the fee schedule, ICD-10, HCPCS, and Local Coverage Determinations.
2027 Fee Schedule Guide
How the CY2027 Medicare Physician Fee Schedule works and what to track.
ICD-10 Change Center
The FY2027 ICD-10-CM update cycle and the October 1 effective date.
HCPCS Quarterly Update
How HCPCS Level II changes every quarter — Jan, Apr, Jul, Oct.
Tracking LCD Changes
How LCDs change across every MAC jurisdiction and how to track them.
2027 Prep Checklist
A free, printable checklist for the CY2027 fee schedule cycle.
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